The skin follows two distinct instructions for synthesis and breakdown processes. When the breakdown signals (such as IL-1, IL-6, etc.) are issued, cells secrete enzymes to degrade extracellular matrix components like collagen, hyaluronic acid, elastin, and others. Conversely, upon receiving the synthesis signal TGF-β, dermal fibroblasts proliferate, initiating a substantial synthesis of extracellular matrix components.
Therefore, merely supplementing abundant beauty-enhancing ingredients may not suffice. Without crucial signaling cues, skin cells cannot achieve the desired effects.

Int J Mol Sci. 2021 Apr 12;22(8):3974.
TGF-β, Transforming growth factor beta: is a multifunctional protein that can influence various cellular functions including growth, differentiation, apoptosis, and immune regulation.